Rad17, the clamp loader that loads more than clamps | The
Mar 11, 2014 · Rad17 is best known as a checkpoint clamp loader in the activation of ATR kinase signaling. A new study in The EMBO Journal suggests that it also plays a role in initial recruitment of the MRN complex to sites of DNA double-strand breaks, thereby promoting early ATM checkpoint responses and homologous recombination repair. The cellular response
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HDF1 and RAD17 genes are involved in DNA double-strand
2017 / 03 / 23 HDF1 and RAD17 genes are involved in DNA double-strand break repair in stationary phase Saccharomyces cerevisiae
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Anti-RAD17 (C-terminal) antibody produced in rabbit ~1 mg
RFC-like DNA damage sensor (RAD17)/checkpoint clamp loader component participates in DNA replication, repair and modification or chromatin remodeling. Phosphorylation of RAD17 is a critical event during checkpoint signaling in DNA-damaged cells. RAD17 has been reported in colon, breast and non-small cell lung carcinoma.
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rad17 - RAD17 checkpoint clamp loader component - …
RAD17 checkpoint clamp loader compo RAD17 checkpoint clamp loader component. rad17. 666. Annotation score: Annotation score:2 out of 5. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the
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Genomic instability and endoreduplication triggered by
Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage and replication stress. To explore the role of Rad17 in the maintenance of genomic integrity, we established somatic conditional alleles of RAD17 in human cells.
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RAD17 - DNA damage checkpoint control protein RAD17
Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17. The interaction with MEC3 is performed in a RAD17-dependent manner. The checkpoint clamp complex loads onto DNA. Interacts with the DNA polymerase zeta subunit REV7. 2 RAD17 subunits form also a hetero trimer with one MEC3 subunit. 7 Publications
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RAD17 | Cancer Genetics Web
Gene: RAD17; RAD17 checkpoint clamp loader component: Aliases: CCYC, R24L, RAD24, HRAD17, RAD17SP : Location: 5q13.2: Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage.
Get a quoteRad17, the clamp loader that loads more than clamps
Rad17, the clamp loader that loads more than clamps Tanya T Paull1,2 & Ji-Hoon Lee1,2 Rad17 is best known as a checkpoint clamp loader in the activation of ATR kinase signaling. A new study in The EMBO Journal suggests that it also plays a role in initial recruitment of the MRN complex to sites of DNA double-strand breaks, thereby
Get a quoteRAD17 RAD17 checkpoint clamp loader component - …
Mar 02, 2021 · RAD17 RAD17 checkpoint clamp loader component Gene ID: 5884, updated on 2-Mar-2021 Gene type: protein coding Also known as: CCYC; R24L; RAD24; HRAD17; RAD17SP. Go to complete Gene record for RAD17; Go to Variation Viewer for RAD17 variants; Summary. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces
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rad17 - RAD17 checkpoint clamp loader component - …
RAD17 checkpoint clamp loader component. Gene. rad17. Organism. Danio rerio (Zebrafish) (Brachydanio rerio) Status. Unreviewed-Annotation score: -Experimental evidence at protein level i. Function i GO - Molecular function i. ATP binding …
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HDF1 and RAD17 genes are involved in DNA double-strand
2017 / 03 / 23 HDF1 and RAD17 genes are involved in DNA double-strand break repair in stationary phase Saccharomyces cerevisiae
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Clamp and clamp loader structures of the human checkpoint
The checkpoint protein complexes, Rad9-Hus1-Rad1 (RadLiming) and Rad17-RFCs2-5 (Rad17-RFC), have been predicted to function as novel clamp and clamp loader proteins, respectively, due to their amino acid sequence similarities with PCNA and RFC. Results: We reconstituted human RadLiming and Rad17-RFC complexes in insect cells using a baculovirus
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RAD17 RAD17 checkpoint clamp loader component [ …
RAD17 RAD17 checkpoint clamp loader component [ (human)] Gene ID: 5884, updated on 7-Nov-2021. Summary. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong
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RAD17 (RAD17 checkpoint clamp loader component)
RAD17 (RAD17 checkpoint clamp loader component), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
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rad17 - RAD17 checkpoint clamp loader component - Danio
RAD17 checkpoint clamp loader component. Gene. rad17. Organism. Danio rerio (Zebrafish) (Brachydanio rerio) Status. Unreviewed-Annotation score: -Experimental evidence at protein level i. Function i GO - Molecular function i. ATP binding …
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Anti-RAD17 (C-terminal) antibody produced in rabbit ~1 mg
RFC-like DNA damage sensor (RAD17)/checkpoint clamp loader component participates in DNA replication, repair and modification or chromatin remodeling. Phosphorylation of RAD17 is a critical event during checkpoint signaling in DNA-damaged cells. RAD17 has been reported in colon, breast and non-small cell lung carcinoma.
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RAD17 RAD17 checkpoint clamp loader component [ (dog)]
RAD17 RAD17 checkpoint clamp loader component [ (dog)] Gene ID: 478088, updated on 3-Sep-2016. Summary Other designations. cell cycle checkpoint protein RAD17, RAD17 homolog
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RAD17 related genes - GeneCards Search Results
Symbol Description Category GIFtS GC id Score; 1: RAD17: RAD17 Checkpoint Clamp Loader Component: Protein Coding: 41: GC05P069369: 64.06: 2: RAD17P2: RAD17 Pseudogene 2
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Product Details
RAD17 Entrez Gene ID 5884 Gene Name: RAD17 checkpoint clamp loader component Gene Aliases CCYC, HRAD17, R24L, RAD17SP, RAD24 Gene Chromosome Location Chr.5: on Build GRCh38 UniGene Hs.16184 Species: Human Primer Chromosome Location Chr.5: 69371336-69371858 on Build GRCh38 View in UCSC browser
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Requirement for ATP by the DNA damage checkpoint clamp loader
The DNA damage clamp loader replication factor C (RFC-Rad24) consists of the Rad24 protein and the four small Rfc2-5 subunits of RFC. This complex loads the heterotrimeric DNA damage clamp consisting of Rad17, Mec3, and Ddc1 (Rad17/3/1) onto partial duplex DNA in an ATP-dependent manner. Interaction …
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